Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
6. 《出租车》(Taxi)，导演贾法·帕纳西(Jafar Panahi)。
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
4. Slacking at school
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
This story pulls directly from the real Bling Ring gang , whose burglaries racked up $3 million over the span of ten months in 2008. All of the celebrities listed in the movie were real victims of this group, who claim to have been motivated by the "cultural obsession" surrounding celebrities' personal lives. Whatever their motives, the Bling Ring is a good reminder to take a step back from the media every once in a while.
Trends and targets in antiviral phototherapy
But as Western manufacturing and industry have declined, taking many working-class towns with them, parents and grandparents have found that the opportunities they once had are unavailable to the next generation.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Collins grew up in rural, apartheid-era South Africa in the 1970s. Her childhood inspired her to focus on empowering women living below the poverty line through grassroots efforts. The Wonderbag, which was inspired by watching her grandmother cook with cushions, uses heat retention technology to cook food for 8-12 hours without the need for additional fuel. Collins witnessed the benefits African women received from using Wonderbags, reducing the amount of time they spent collecting firewood. For every bag sold, another is donated to a household in Africa, and in the past four years, the Wonderbags have found themselves in 600,000 African homes. Collins has launched the Wonderbag in the U.S. on Amazon, and hopes to sell the products via other retailers by 2014.
Novel biosensing methodologies for ultrasensitive detection of viruses
The survey is based on costs of over 160 items ranging from food and clothing, to domestic help, transport and utilities.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
The world’s 100 biggest brands still command a significant premium over others and that value increased by 3 per cent to $3.4tn this year, according to the latest BrandZ rankings compiled by Millward Brown, the research agency.
6. statuesque / a . 高大匀称的，体态优美的。
ACE2 as a potential therapeutic target for pandemic COVID-19
Emissions have been falling gradually in recent years in most of the developed countries, in part because of economic weakness but also because of strengthening climate policies. Emissions in the 28-nation European Union fell 1.8 percent in 2013, despite increases in coal consumption in a few countries, including Germany and Poland. Emissions decreased sharply in Britain, Italy and Spain.
Diagnostic technologies for COVID-19: a review
Prices at China's factory gates fell for a 34th consecutive month in December, pushed down by falling energy and commodity prices.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Chinese Premier Li Keqiang delivers a government work report during the opening meeting of the fourth session of the 12th National People's Congress at the Great Hall of the People in Beijing, capital of China, Mar 5, 2016.
That was in line with last month’s manufacturing PMIs, which showed an uptick in sector activity,
达洛伊西奥的父母从澳大利亚搬到英国，他的父亲卢(Lou)曾在英国石油(BP)和摩根士丹利(Morgan Stanley)工作，而母亲戴安娜(Diana)是一位企业律师，同时也是儿子的合同代表。他们向来都知道达洛伊西奥是一个非常好学的孩子。但戴安娜说因为他是长子，他们本以为他不会做出什么超出寻常的事情来（达洛伊西奥有一个14岁的弟弟）。他们强调，尽管达洛伊西奥成就非凡，尽管他聊天时会聊起马尔科夫模型(Markov models)和随机过程(stochastic processes)，他仍只是一个再普通不过的孩子。戴安娜说，他周末仍要出去玩，仍要去参加派对。他还有个女朋友。17岁孩子会做的事情，他都会做。
Bryant is the first player this season with four or fewer points on 14 or more field goal attempts.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
I empathize with the Mavs' position. It's tough to tell your fans that all hope is lost in November, and it's especially tough when you've got a Hall of Famer still on your roster.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
3．50 First Dates
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Edgar Wright’s Baby Driver is one of the most entertaining thrill rides of this year, this decade. This century.
Antiviral drug discovery: broad-spectrum drugs from nature
Two against-the-clock tours of Los Angeles. Two celebrations of the sometimes prickly solidarity among women. Four tremendous performances, from Kitana Kiki Rodriguez, Mya Taylor, Julia Garner and the great Lily Tomlin. “Grandma” is the work of a studio veteran. “Tangerine” was shot on iPhones. Anyone prone to lamenting the death of movies needs to shut up and watch these.
4. How to draw manga
9.Beating Hearts Created In A Petri Dish
Influenza neuraminidase: A druggable target for natural products
With the momentum now back behind the iPhone and anticipation growing for the Watch, Mr Cook seems to have won back the confidence of Apple employees, something that analysts say was obvious in his demeanour at this year’s product launches.
"Look What You Made Me Do" is one for the history books, and pop scholars will likely debate for generations whether it was a brilliant P.R. coup or not.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Belmonte's 1950 ticket will be displayed at a Zurich museum that is set to open in 2015, according to Jerome Valcke, FIFA's secretary general. "This is something rare we would like to have for the museum," he said.
The role of biosensors in the detection of emerging infectious diseases
'She does wear wigs and crowns and fancy dresses but I don't give her spray tans or cake her in makeup - I'll wait until she's about five for that.'
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The committee *bestowed the award upon Yoshinori Ohsumi of the Tokyo Institute of Technology, for his research on *autophagy, which is a self-eating process seen in cells.
2. Google Docs
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
n. 慈善，慈善机关(团体), 仁慈，宽厚
Song “Chang’er”(Li Yugang and three Chinese astronauts)
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Many grand and spectacular museums are located in picturesque cities like Bruges, Antwerp and Brussels. Art lovers can fully engage themselves in the numerous treasures dating back to the medieval period. Exploring the quiet towns and appreciating their Gothic architecture is also an opportunity not to be missed. As the hometown of the world’s best beers, chocolates and fries, everyone can be a gourmet here. With the 100th anniversary of the outbreak of World War I approaching, Belgium is set to draw many tourists in the coming years.
'People in the community are affected by what I write, ' he says.
According to a research report on 2016 graduates released by 51job.com, a leading job hunting platform in China, 52.11% of college graduates found employment or started their own business.
Look no further than the title sponsor on their building—Smoothie King, a regional drink shop—to realize that the Pelicans have a serious relevancy problem. (By contrast, the NFL's Saints play in the Mercedes-Benz Superdome next door.)
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Four government agencies including the commerce ministry and the central bank said in December they would apply tighter scrutiny to "irrational" outbound deals including real estate, hotels, movie theatres, entertainment assets and sports clubs.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Rounding out the top three is Chrissy Teigen, 31, who joins the list for the first time after raking in $13.5 million over the past 12 month-period.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
So far this year, companies have announced 376 share-repurchase initiatives for a total of $261 billion, according to data from Birinyi Associates. That's nearly 72% higher than 2012, though slightly lower when compared to the same period in 2013, which was a record year for buybacks.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Martha Cherry took a cigarette out of her mouth, murmured, "I've been there," and resumed smoking. Marc was in shock (which, let's face it, is a pretty healthy response when you realize your own mother may or may not have had thoughts of murdering you while you bathed). He realized for the first time how desperate and lonely it could be to be a housewife. He realized then and there that he was upon a very good idea for a TV show. This conversation was the birth of Desperate Housewives.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
This changed two years ago, though, when Tsinghua University broke into the top 20 for the first time, ranking 18th in 2016. Last year, Peking University joined it in the top 20.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The study relied on a dataset of hundreds of millions of secret answers and millions of account recovery requests.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Domain name registrar GoDaddy, which is based in Scottsdale, Ariz., broke ground in May on its new Global Technology Center in Tempe. GoDaddy already employs 2, 600 people in the Greater Phoenix area and the new facility is expected to add 300 more. Other companies expanding in Arizona include Asurion, a leader in technology protection services. They opened a new technical support center in Phoenix and want to fill 500 jobs by the end of the year. Energy provider Direct Energy opened a new call center in Tempe this year and is looking to fill as many as 300 openings.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
transport（n /v 运输；狂喜），trans转移，port搬运
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Lana Del Rey, 'Lust for Life'
The BFC's news has been met with support from people on social media, who have applauded the designers choosing to forgo the use of animal fur.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
But the carriers are having a more difficult time over the winter holidays. About 30 percent of winter holiday flights were delayed in 2012, on top of significant delays in 2011 and 2010. You can check holiday flight statistics from the Transportation Department on its website.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Remember, no one is ever perfectly prepared for every situation. You’ve probably discovered this by now. Your education gave you a foundation for the job, but growth happens in the trenches. Maybe you motivated your team not just to meet the new deadline, but to deliver extraordinary work. Perhaps you realized you had more poise than you ever expected in a client situation. Or, you suddenly discovered that you can capitalize on the relationships you’ve built and become a “rainmaker” for your organization. Before you can learn any of these things, you have to learn to say “Yes.” It’s okay to acknowledge the butterflies in your stomach; however, it’s not okay to let them stifle your growth.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
China's economic performance in the past few years should suffice to put predictions of a hard landing to a full stop. China's economy will continue to enjoy medium-high growth and be upgraded to higher levels
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
A total of 16 Chinese companies are in the top 100 on the list, including China Mobile, Alibaba and Tencent.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
It has now entered the top 20 for the first time.
Under the Skin is just so visually free and uninhibited that there is an intense dark, destructive sexiness in everything about it – quite apart from the hilarious, bizarre, mesmeric eroticism of the film itself. It is a work of subcutaneous potency. It gets under your skin.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Once Upon A Time
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Except your Watson, he thinks it's hot.
9) Well Done: It’s a cliché, no doubt. Sometimes, it isn’t enough just to say thanks. People want to know what they did was great and why. They pour so much sweat and soul into their projects.They need to know their work was special and had meaning to someone.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
The hair creates a resemblance to the look of Michelle Pfeiffer, but Ms. Chastain gives it more of an edge. Kay Georgiou, who frequently styles the hair of Matt Damon and Gwyneth Paltrow for films, oversaw the look.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The cities of Hefei and Xiamen once again led the pack with growth of 48.6 per cent and 45.9 per cent, respectively.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
China does not want to resort to yuan depreciation to boost exports as that would dampen the restructuring and upgrading of the corporate sector.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Detroit Three: The other two Michigan-based manufacturers still face bumps. General Motors copes with continued fallout from its ignition switch recall while Ford fights through the most aggressive launch period in the company’s history.
As the new iPhone continues to smash its own launch records, Mr Cook has unveiled products such as Apple Watch and Apple Pay that take the iPhone maker into the realms of fashion and finance, recapturing a spirit of innovation that many feared had died with Jobs. In the process, Apple’s valuation this year has grown by almost as much as Google’s entire market capitalisation.
A facile assay for rapid detection of COVID-19 antibodies
The QUBE will remind you to recycle, monitor when the trash was last taken out, and tell you to change the air freshener. These are all things people usually remember to do anyway, by the smell and all, but now there's a $300 "elegant" stainless steel can that'll constantly remind you with annoying mobile alerts.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
《风骚律师》(Better Call Saul)，AMC，2月8日播出。这是文斯·吉里根(Vice Gilligan)与彼得·古尔德(Peter Gould)的《绝命毒师》的衍生剧，或许是今年冬天最受期待的新剧了。鲍勃·奥登科克(Bob Odenkirk)饰演狡猾的律师索尔·古德曼(Saul Goodman)，剧情设定在《绝命毒师》的故事发生之前，所以布莱恩·克莱斯顿(Bryan Cranston)或亚伦·保罗(Aaron Paul)至多只是客串出演而已。但观众们最喜欢的乔纳森·班克斯(Jonathan Banks)将在里面重现他在《绝命毒师》中的角色——冷静的行动执行者迈克·厄尔曼特劳特(Mike Ehrmantraut)。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
As a measure of that fall, 10 works have sold at auction for more than $100 million since 2004, and all of them were made by modern or contemporary artists in the past 120 years. Older paintings have seen their value, in relative terms, level off or decline. The trend was plain to see in recent weeks, as London’s auction houses tried to find buyers for their latest tranche of old masters. As has been the case in recent years, there were few works by major names.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The data showed that Samsung took the top spot, followed by Apple in second place. Even so, the shipments of the two top tech giants declined respectively by 3 percent and 7 percent, demonstrating decreased global market shares.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
It set minimum prices too high for commodities including cotton, sugar and corn, and as those prices diverged from the market prices, authorities encouraged excessive production as well as strong import flows.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Cheng further says, "once you find a list that fits your needs, just tap on the list to see suggested locations. Then swipe right or left to see more options and tap 'read more' or the arrow at the bottom of the screen to select a venue and get more details.".
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
这些新数据是由一个叫做全球碳计划(Global Carbon Project)的追踪项目提交的，发表在了期刊《自然·地球科学》(Nature Geoscience)上。数据公布之际，正是联合国(United Nations)一次峰会召开前夕。此次峰会意在激发新的政治愿望来解决气候变化问题。科学家说，这些数据表明，如果要把长期的全球变暖问题控制在可以承受的范围内，还需要做出极大的努力。
Anti-HIV drug repurposing against SARS-CoV-2
“A worker sent a text to a colleague saying he was quitting and asked her to forward it to management.”
Length-scale dependence of protein hydration-shell density
We will promote a steady increase in consumer spending.
Economists had forecast a 1.5 per cent annual rate, after a 1.6 per cent reading in September. Beijing's inflation target is "around 3 per cent" this year.
6. Our last universal common ancestor gets a makeover
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
伦敦商学院在所有这5项排名上表现强劲。其所有课程都跻身欧洲前十，包括全日制MBA课程排名第二，合办EMBA（与美国哥伦比亚商学院(Columbia Business School)合办）和定制高管教育课程均排名第四。
Guangdong has cemented its position as the country's largest provincial economy for the 28th consecutive year, with its gross domestic product (GDP) exceeding 7.9 trillion yuan in 2016.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
About this collection
Cliff Stevenson, an anti-dumping expert who publishes the report based on data filed with the WTO, said the surge in US cases was driven largely by the steel industry. The increase also represented the range of countries from China to Australia, the UK and the Netherlands against which US companies were willing to file anti-dumping complaints.
Many believe the population is no longer a major threat to China's resources and environment. Instead, China's population challenges have shifted to low birth rates, an aging society and a widening gender imbalance. China has already experienced a shortage of skilled workers in places like the Pearl River Delta, so it might not be long before we see major reforms.